[CaRP] (-1073781400)
First drug-delivery particles capable of passing through human mucus
by Mary Carter
15 Sep 2008 at 5:00pm
Chemical engineers from Johns Hopkins University have broken the "mucus barrier," engineering the first drug-delivery particles capable of passing through human mucus - regarded by many as nearly impenetrable - and carrying medication that could treat a range of diseases.Those conditions include lung cancer, cervical cancer and cystic fibrosis, the research noted in a presentat... Click on title for full news .... The effect of freeze-dried black raspberries on genes altered by chemical car...
by Lisa Martin
15 Sep 2008 at 5:00pm
New research strongly suggests that a mix of preventative agents, such as those found in concentrated black raspberries, may more effectively inhibit cancer development than single agents aimed at shutting down a particular gene.Researchers at the Ohio State University Comprehensive Cancer Center examined the effect of freeze-dried black raspberries on genes altered by a chemic... Click on title for full news .... New targets for vascular normalization therapy
by Jennifer Davis
15 Sep 2008 at 5:00pm
Chemotherapy drugs often never reach the tumors they're intended to treat, and radiation therapy is not always effective, because the blood vessels feeding the tumors are abnormal-"leaky and twisty" in the words of the late Judah Folkman, MD, founder of the Vascular Biology program at Children's Hospital Boston.Now, Vascular Biology researchers have discovered an explanation fo... Click on title for full news .... The link between low folate intake and an increased risk for colon cancer
by Monica Tele
15 Sep 2008 at 5:00pm
Researchers in the United Kingdom and Texas are reporting a new, more detailed explanation for the link between low folate intake and an increased risk for colon cancer, the second leading cause of cancer death in the United States.Their study reinforces the importance of folate in a healthy diet.Susan Duthie and colleagues note that researchers have known for years that a defi... Click on title for full news .... Tanning Dependence, Common Among University Students
by Johnson Smith
15 Sep 2008 at 5:00pm
A new study conducted at a large university finds more than 25 percent of those surveyed reported symptoms of tanning dependence, including symptoms similar to alcohol and drug-addicted individuals.Suggestively, the study also found those with a tanning dependence tend to be more likely to be thin and smoke cigarettes than others. The study by researchers at Fox Chase Cancer Ce... Click on title for full news .... High-resolution structure of a mammalian fatty acid synthase Determined
by Mary Carter
15 Sep 2008 at 5:00pm
Mammalian fatty acid synthase is one of the most complex molecular synthetic machines in human cells. It is also a promising target for the development of anti-cancer and anti-obesity drugs and the treatment of metabolic disorders. Now researchers at ETH Zurich have determined the atomic structure of a mammalian fatty acid synthase.Synthesis of fatty acids is a central cellular... Click on title for full news .... Synthetic Molecules that can fight breast and prostate cancer cells
by Jennifer Davis
2 Sep 2008 at 5:00pm
Seeking to improve on nature, scientists used a spice-based compound as a starting point and developed synthetic molecules that, in lab settings, are able to kill cancer cells and stop the cells from spreading.The researchers are combining organic chemistry, computer-aided design and molecular biology techniques in developing and testing pharmaceutical compounds that can fight ... Click on title for full news .... The Role Of Particle Shape And Size In Nanomedicine Therapies
by Monica Tele
22 Aug 2008 at 5:00pm
In the budding field of nanotechnology, scientists already know that size does matter.But now, researchers at the University of North Carolina at Chapel Hill have shown that shape matters even more - a finding that could lead to new and more effective methods for treating cancer and other diseases, from diabetes and multiple sclerosis to arthritis and obesity.A team of researche... Click on title for full news .... Anti-parasite Drug Targets chemotherapy-resistant malignant melanoma
by Jennifer Davis
22 Aug 2008 at 5:00pm
Researchers at the NYU Cancer Institute and the Ronald O. Perelman Department of Dermatology have identified mebendazole, a drug used globally to treat parasitic infections, as a novel investigational agent for the treatment of chemotherapy-resistant malignant melanoma.Because most patients with metastatic melanoma fail to respond to available therapies, the discovery of a viabl... Click on title for full news .... Combination of hadrontherapy and addition of heavy atoms Destroy Tumor Cells
by Stroe Sorin
22 Aug 2008 at 5:00pm
A new discovery has been made in cancer research. Researchers from the Laboratoire des collisions atomiques et moléculaires (CNRS/Université Paris 11) and the Laboratoire Génotoxicologie et cycle cellulaire (CNRS/Institut Curie) were the first to show that it is possible to improve hadrontherapy's(1) targeting and destruction of tumor cells by loading the cells w... Click on title for full news .... Special Schools - Sex and Relationship Education
by Teachers TV
13 May 2008 at 11:30am
Pioneering work on SRE at Shepherd School in Nottingham
read more
Every Child Matters - Tom's Team
by Teachers TV
6 May 2008 at 10:00am
What happens when children's services don't communicate?
read more
The Teaching Challenge - Comedy Dave
by Teachers TV
26 Mar 2008 at 12:30pm
Comedy Dave leads a group of inner city children on an adventure
read more
KS1/2 Maths - Learning Maths with Kyane
by Teachers TV
10 Mar 2008 at 5:00am
Follow a lesson on 3D shapes through the eyes of a Year 4 pupil
read more
KS1/2 Science - Learning Science with Kyane
by Teachers TV
5 Mar 2008 at 4:00am
Examining Year 4 pupil Kyane during a science lesson on friction
read more
School Matters - I am Bovvered
by Teachers TV
12 Feb 2008 at 11:30am
One dedicated teacher takes a huge risk to help troubled girls
read more
When it comes to preventing amputation
28 Nov 2007 at 10:56pm
Scientists at Scholl College's Center for Lower Extremity Ambulatory Research (CLEAR) at Rosalind Franklin University of Medicine and Science, Leiden University in the Netherlands, and Texas AandM University have presented important new information that could help physicians and their patients predict dangerous recurrent wounds that precede amputations in persons with diabetes. The study, conducted over a several-year period, identified two simple items that helped predict recurrence........Potential New Target For Type 2 Diabetes
28 Nov 2007 at 10:56pm
Researchers at the University of Pennsylvania School of Medicine have discovered a potential new target for treating type 2 diabetes, according to a new study that appeared online this week in Nature. The target is a protein, along with its molecular partner, that regulates fat metabolism. ?Over the last 10 years, we have begun to understand the importance of fat metabolism in diabetes,? notes lead author Morris J. Birnbaum, MD, PhD, the Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases at Penn and an Investigator of the Howard Hughes Medical Institute. ?Type 2 diabetics are at a higher risk for cardiovascular disease because they also have disorders in fat metabolism as a result of obesity and abnormal insulin action.? Birnbaum is also the Associate Director of the Type 2 Diabetes Unit for Penn?s Institute for Diabetes, Obesity, and Metabolism........helping obese diabetics lose weight
28 Nov 2007 at 10:56pm
A plate and cereal bowl with markers for proper portion sizes appear to help obese patients with diabetes lose weight and decrease their use of glucose-controlling medications, according to a report in the June 25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. Between 1960 and 2000, the proportion of U.S. adults who were obese increased from 13.4 percent to 30.9 percent, according to background information in the article. Most cases of type 2 diabetes can be attributed directly to obesity. Restricting calories has been shown to improve blood sugar control in diabetics, partially by contributing to weight loss. The increasing prevalence of obesity is paralleled by increasing portion sizes in the marketplace, the authors write. Portion sizes are an important determinant of energy intake; the number of calories ingested by subjects at a meal has been directly correlated with the serving size offered........Cord blood may preserve insulin levels in children with type 1 diabetes
28 Nov 2007 at 10:56pm
Umbilical cord blood may safely preserve insulin production in children newly diagnosed with type 1 diabetes, as per findings from a small national pilot study presented Monday (June 25) at the American Diabetes Associations 67th Scientific Sessions in Chicago. University of Florida scientists sought to determine whether it is feasible to use a patients own cord blood stem cells to neutralize the bodys autoimmune attack on the pancreas and help restore the organs ability to make insulin, which regulates how the body uses sugar and other nutrients for energy........Pharmacists To Help Diabetes Sufferers
28 Nov 2007 at 10:56pm
A new Wesley Research Institute project aims to make it much easier for people to manager their Type 2 Diabetes by using community pharmacists. There are more than one million Australians with Type 2 Diabetes who are at an increased risk of developing serious health problems including heart disease, stroke, kidney disease and blindness........Rosiglitazone for type 2 diabetes
28 Nov 2007 at 10:56pm
New studies are needed to assess the trade-offs between potential benefits and potential harms when rosiglitazone is used by people with type 2 diabetes. This Cochrane Systematic Review analysed data from 18 trials that involved a total of 8432 people and found no evidence that rosiglitazone led to better patient outcomes when compared with other therapies. Diabetic control (as measured by levels of HbA1c) was no better in patients given rosiglitazone when in comparison to other antidiabetic drugs. Patient oriented outcomes such as mortality, diabetes related morbidity, or quality of life were not addressed in most studies........Shielding the brain from too much insulin can prolong life
28 Nov 2007 at 10:56pm
One route to a long and healthy life may be establishing the right balance in insulin signaling in the body and brain, as per new research from Children's Hospital Boston. The study, reported in the July 20 issue of Science, not only reinforces the value of exercising and eating in moderation, but also helps explain a paradox in longevity research........How insulin secreting cells maintain their glucose sensitivity
28 Nov 2007 at 10:56pm
Researchers at the leading Swedish medical university Karolinska Institutet have now disclosed the mystery how the insulin-secreting cells maintain an appropriate number of ATP sensing ion channel proteins on their surface. This mechanism, which is described in the latest number of Cell Metabolism, explains how the human body can keep the blood glucose concentration within the normal range and thereby avoid the development of diabetes........Periodontal diseases and pre-diabetes
28 Nov 2007 at 10:56pm
Periodontal diseases may contribute to the progression to pre-diabetes, as per a new study that appears in the recent issue of the Journal of Periodontology. Pre-diabetes is a condition in which blood glucose levels are higher than normal, but not high enough to be diagnosed as diabetes. The American Diabetes Association estimates 54 million people in the United States have pre-diabetes, and a significant portion of those people will develop Type 2 diabetes within 10 years........Erectile dysfunction in diabetics
28 Nov 2007 at 10:56pm
A new study sheds additional light on how erectile dysfunction (ED) interacts with diabetes. The study is another step in uncovering the link between the two disorders, and may lead to improved efficacy in therapys. The study, "Lack of Central Nitric Oxide Triggers Erectile Dysfunction in Diabetes," was conducted by Hong Zheng, William G. Mayhan, and Kaushik P. Patel, Departments of Cellular and Integrative Physiology; and Keshore R. Bidasee, Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE. The results appear in the March 2007 edition of the American Journal of Physiology Regulatory, Integrative and Comparative Physiology, one of 11 peer-reviewed scientific publications issued monthly by The American Physiological Society (APS) (www.The-APS.org)........Supplement Inhibits Multiple Sclerosis, Type 1 Diabetes
28 Nov 2007 at 10:56pm
A glucosamine-like dietary supplement has been found to suppress the damaging autoimmune response seen in multiple sclerosis and type 1 diabetes mellitus, as per University of California, Irvine health sciences researchers. In studies on mice, Dr. Michael Demetriou and his colleagues with the UC Irvine Center for Immunology observed that N-acetylglucosamine (GlcNAc), which is similar but more effective than the widely available glucosamine, inhibited the growth and function of abnormal T-cells that incorrectly direct the immune system to attack specific tissues in the body, such as brain myelin in MS and insulin-producing cells of the pancreas in diabetes. Findings from the study are published on the online version of the Journal of Biological Chemistry........Illuminating Cause Of Diabetes
28 Nov 2007 at 10:56pm
Any photographer can vouch for the difficulty of capturing a clear picture of a moving target. When it comes to molecules, however, sometimes the motion is exactly what researchers want to see - for example, to understand the pathological protein mis-folding and assembly that seem to underlie a host of human disorders, including diabetes and Alzheimer's disease........Sleep apnea may increase risk of diabetes
28 Nov 2007 at 10:56pm
Scientists at the Yale University School of Medicine have observed that patients with obstructive sleep apnea are at increased risk for developing of type II diabetes, independent of other risk factors. The findings are being presented at the American Thoracic Society 2007 International Conference, on Monday, May 21........How insulin TORC2 blood sugar levels
28 Nov 2007 at 10:56pm
La Jolla, CA With the help of genetically engineered mice whose livers turned into glowing light bulbs, scientists at the Salk Institute for Biological Studies have illuminated the underpinnings of an insidious and growing health concern type II diabetes. In the study reported in the September 5 advanced online edition of Nature, the scientists report that a protein called TORC2 serves as a key biochemical control point linking feeding, insulin, and elevated blood sugar production in the liver. The findings highlight TORC2 and an enzyme called SIK2 as potential drug targets for treating type II diabetes........Transporters and diabetes-related retinal damage
28 Nov 2007 at 10:56pm
Two transporters that deliver alternative energy sources to the eye may help delay retinal damage that can occur in diabetes, scientists say. The transporters, SMCT1 and SMCT2, can circumvent the eye's protective blood-retinal barrier, delivering energy sources lactate and ketone bodies to a healthy eye, says Dr. Pamela Martin, biochemist at the Medical College of Georgia........Resource Review Special - Special Educational Needs
by Teachers TV
8 Nov 2007 at 11:30am
A look at six resources for special educational needs
read more
Primary SEN - Circle of Friends - Ben
by Teachers TV
8 Nov 2007 at 11:00am
How the Circle of Friends system is benefiting SEN pupil BEN
read more
Estelle Morris Meets - Baroness Warnock
by Teachers TV
7 Nov 2007 at 11:30am
Estelle Morris speaks with SEN expert Baroness Warnock
read more
Secondary Special Needs - SEN Pupils in Transition
by Teachers TV
6 Nov 2007 at 4:00pm
How one school meets the needs of present and future SEN pupils
read more
